If you've noticed that your energy, mental clarity, or recovery time isn't quite what it was a decade ago, you're not imagining it — and it's not just lifestyle. There's a measurable biological reason: your cells are producing less NAD+.
What Is NAD+ and Why Does It Matter?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell in your body. It plays a central role in energy metabolism, DNA repair, and cellular communication. Without adequate NAD+, your mitochondria — the energy factories of your cells — simply can't function at full capacity.
The problem is that NAD+ levels decline significantly with age. Research published in peer-reviewed journals has shown that NAD+ levels in human tissue can fall by 50% or more between the ages of 40 and 60. This decline has been directly linked to hallmarks of aging including reduced metabolic efficiency, increased fatigue, impaired cognitive function, and slower tissue repair.
The NMN Connection
NMN (nicotinamide mononucleotide) is a direct precursor to NAD+. When you take NMN, your body converts it into NAD+ through a well-established biosynthetic pathway. This is why NMN supplementation has become one of the most studied approaches to supporting NAD+ levels in aging adults.
A multicenter, randomized, double-blind, placebo-controlled clinical trial demonstrated that NMN supplementation significantly and safely increased blood NAD+ levels in healthy adults. Participants taking NMN showed measurable increases in NAD+ concentrations within weeks, with the response being dose-dependent — the higher the dose, the greater the NAD+ elevation.
Additional research published in peer-reviewed journals has found that participants supplementing with NMN showed improvements in walking endurance compared to placebo, with those at higher doses demonstrating the greatest gains. Importantly, biological age markers stabilized in the NMN groups while continuing to increase in the placebo group — a finding that points toward a genuine anti-aging effect at the cellular level.
Glucose, Lipid Metabolism, and Beyond
A meta-analysis examining the metabolic effects of NMN found that supplementation had favorable effects on both glucose and lipid metabolism. This is consistent with NAD+'s role in activating sirtuins — a family of proteins that regulate metabolic homeostasis and have been extensively studied in the context of longevity.
The Novara Approach
Novara NMN+ is formulated with 500mg of pharmaceutical-grade NMN per serving — a dose consistent with the ranges used in clinical research. We use no fillers, no proprietary blends, and no unnecessary additives. Every batch is third-party tested for purity and potency.
NAD+ decline is one of the most well-documented aspects of the aging process. Supporting your NAD+ levels with NMN is one of the most direct, evidence-based interventions available today.
References: Yoshino et al., Cell Metabolism; Mills et al., Cell Metabolism; Liao et al., Frontiers in Pharmacology; Irie et al., NPJ Aging and Mechanisms of Disease.